患有抽动秽语综合征的女主人公奈娜。经过无数次面试失败后，终于找到理想的工作，成为了一名中学老师。然而她被指派的班级学生却是全校最顽皮的学生。

Anniyan is the story of Ramanujam "Ambi" Iyengar (Vikram), a lawyer who suffers from Multiple Personality Disorder. Ambi is an innocent and honest lawyer. If he comes across anyone not obeying the rules he files cases against them but all his efforts go in vain. 　　His constant habit to be perfect in rules and honesty leads him to develop a Multiple Personality Disorder in which a new character in him grows as Anniyan (Vikram) and starts a website called www.anniyan.com to hear people's complaints. The new character, Anniyan, is a violent man. When he is Ambi and comes across a person who does not obey rules he makes complaints in his website. When he is Anniyan, he goes and kills them by methods used for torturing people in hell. He apparently takes the definition of these methods from the Garuda Purana.