The Horror of Dolores Roach is a grotesque Sweeney Todd-inspired tale of Eat or Be Eaten; a macabre urban legend of love, betrayal, weed, gentrification, cannibalism, and survival of the fittest. It follows the indomitable Dolores Roach, who returns to a New York City neighborhood that has changed drastically during the sixteen years she has been in prison. Her boyfriend missing, her family long gone, Dolores is recognized only by an old stoner friend, Luis, who gives Dolores room and board and lets her give massages for cash in the basement apartment under his dilapidated empanada shop. 　　When the promise of her newfound stability is quickly threatened, ‘Magic Hands Dolores’ is driven to extremes to survive — leaving in her wake a string of strangled massage clients. In the face of unexpected professional success, Dolores and Luis become dangerously symbiotic, and Luis must unleash his own particular predilections.

故事发生在美国西岸的一个小镇中，开发者的到来扰乱了当地居民的平静生活，他们企图将这片人们赖以生存的土地据为己有，对于居民们来说，流离失所的生活似乎在所难免。米奇（西恩·奥斯汀 Sean Astin 饰）和布莱登（乔什·布洛林 Josh Brolin 饰）是一对兄弟，一次偶然中，他们获得了一张年代久远的海盗藏宝图。这一发现让兄弟两人欣喜若狂，因为如果藏宝图所言不假，那么他们就能够守住他们的家园。 　　在朋友们的帮助下，兄弟两人找到了宝藏的入口，它不在别处，正在福瑞特利家的楼下。让众人感到十分头痛的是，这个福瑞特利家族在小镇上有着远扬的坏名声，当宝藏存在的消息不胫而走后，他们显然已经为了能够将其据为己有而展开了行动。