一个邪恶的生育实验创造了一代扭曲的孩子。 一个无情的女人在破坏这些突变的婴儿之前已经做好了这件事，摧毁了这个世界！ 一个母亲和她唯一的朋友在爱之间被撕毁了这个变形的人的排斥，并准备为了生存而战，但这个宝宝不需要爱。 它被编程为不惜一切代价生存。

随着卡诺和黑龙在全球范围内造成严重破坏，一位名叫"剑痴"的年轻战士将不得不超越自己的局限，迎接迫在眉睫的异界威胁。

Aglaé Lanctot, 25-years-old, is as insecure as can be. As a result of being 'brought up' by an irresponsible mother and by an absent father, she can now find her balance only in a methodical life and a regular, well-defined job. For instance in being the most perfectionist vehicle crash test worker ever. So imagine her dismay when she learns that her factory is going to be relocated - in India. Losing such a structuring job is simply inconceivable. So much so that when Aglaé is offered to hold the same position but thousands of miles away from home, with pay cut and without the least social benefits, she - accepts. A few days later, Aglaé hits the road in an old Citroën Visa, accompanied by her two friends and co-workers Liette and Marcelle who, for reasons of their own, have decided to follow her example.

格鲁（史蒂夫·卡瑞尔 Steve Carell 配音）和露西（克里斯汀·韦格 Kristen Wiig 配音）一家即将展开家庭生活的新篇章，迎接新成员“迷你格鲁”，而这个小宝宝也会用尽方法折磨格鲁这个新手老爸。 　　新反派恶霸麦斯（威尔·法瑞尔 Will Ferrell 配音）和他既致命危险又美丽性感的女友瓦伦蒂娜（索菲娅·维加拉 Sofía Vergara 配音）来势汹汹，格鲁一家面临未知危险。此时，全新超级小黄人重磅亮相，成为帮助格鲁一家度过这次危机的“秘密武器”。一场惊险刺激、笑料百出的全新冒险即将展开。